When using;
Windows Remote Desktop Server (RDS) 2012 or above, with
User Profile Disk or
Roaming Profiles
and Acrobat Reader, the user gets the following error:
“There was an error opening this document. Access Denied”
It turn out that the new Adobe Reader software has a Protected Mode feature. This feature has issues with the use of Profile Disks and Roaming profiles. You can disable the Protected Mode under Security (Enhanced) section in Preferences "as a work around". You can also provide exceptions (privileged locations) to the limits imposed by this protected mode to give you access to your PDF files affected by this security enhancement.
IMPORTANT:
Understand the risk of disabling or modifying this Acrobat security feature before deactivating or modifying this security feature.
Protected mode
By default, Adobe Reader DC runs in protected mode to provide an added layer of security. In protected mode, malicious PDF documents can’t launch arbitrary executable files or write to system directories or the Windows Registry.
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